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Draculin is a glycoprotein in vampire bat saliva that inhibits blood coagulation by binding to factors ixa and xa Daily salivation of vampire bats yields a saliva that progressively decreases in. Learn about its structure, function, and glycosylation from this wikipedia article.
Draculin is a 88.5 kda glycoprotein which selectively inhibits both fxa and activated factor ix (fixa) [9] The protein increases the lag phase as well as the height of the peak of thrombin generation when in plasma, leading to prolonged bleeding Furthermore, the anticoagulant activity of draculin is highly dependent on the proper glycosylation of the polypeptide backbone [10].
Draculin is a glycoprotein that irreversibly binds to factors ixa and x, and inhibits the conversion of prothrombin to thrombin [6, 7, 13]
This prevents fibrinogen being converted into fibrin and thus inhibits coagulation of blood during feeding [5]. Draculin, stroke drug from vampire bats, moves closer to circulation vampire bat saliva may revolutionize stroke treatment Its enzyme could break down blood clots better than current methods. Vampire bats produce an anticoagulant called draculin (named for the famous monster) that helps them feed on blood without it clotting
Scientists are studying possible human uses for draculin, such as turning it into an anticlotting agent to prevent or treat strokes. Draculin is a reversible, slow tight binding, noncompetitive inhibitor of fxa It does not act on thrombin, trypsin or chymotrypsin and does not express fibrinolytic activity
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