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Velcade treatment must be initiated under supervision of a physician experienced in the treatment of cancer patients, however velcade may be administered by a healthcare professional experienced in use of chemotherapeutic agents. Each cycle may be repeated up to eight times, depending upon the stage of the disease. The recommended starting dose of velcade is 1.3 mg/m 2
Velcade is administered intravenously at a concentration of 1 mg/ml, or subcutaneously at a concentration of 2.5 mg/ml [see dosage and administration (2.10)]. This is known as one cycle Velcade is for intravenous or subcutaneous use only
Do not administer velcade by any other route
Because each route of administration has a different reconstituted concentration, use caution when calculating the volume to be administered The recommended starting dose of velcade is 1.3 mg/m 2. Medicines used to treat cancer are very strong and can have many side effects. Velcade may be administered intravenously at a concentration of 1 mg/ml, or subcutaneously at a concentration of 2.5 mg/ml [see dosage and administration (2.10)].
Velcade is given as an injection under the skin (subcutaneous injection) or into a vein (intravenous injection) weekly or twice weekly Velcade may be used alone or in combination with other medicines, including rituximab, cyclophosphamide, doxorubicin, melphalan, prednisone, or dexamethasone. Bortezomib is usually given in an outpatient infusion center, allowing the person to go home afterwards Dexamethasone is usually taken at home
Vd is repeated every 21 days
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