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Jaks are a key component of the jak/stat system Numerous cell receptors can activate jak autophosphorylation to promote dna transcription. They are kinases associated with the intracellular domain of type 1 and receptors and exist in four different isoforms
Jak1, jak2, jak3 and tyk2 (schwartz et al., 2017). The four jaks, named jak1, jak2, jak3 and tyk2, form a group of nonreceptor protein tyrosine kinases, important for the regulation and development of immune and hematopoietic cells Currently, jak inhibitors are used to treat ulcerative colitis, but they are also being studied in clinical trials for crohn’s disease
While their approval for ulcerative colitis is recent, they have been in use for rheumatoid arthritis since 2012.
It is unclear which jak isoform (selectivity) confers impact on the efficacy or influences the safety of these therapies for their licenced indications (e.g In this review, we discuss the current knowledge about the composition, activation, and regulation of the jak/stat pathway Moreover, we highlight the role of the jak/stat pathway and its.
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