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An ideal linker should be stable in the circulatory system and release the cytotoxic payload specifically in the tumor This architecture allows adcs to function as guided missiles in oncology—homing in on cancer. Target, antibody, linker, payload, and conjugation method.
The linker has a key role in adc outcomes because its characteristics substantially impact the therapeutic index efficacy and pharmacokinetics of these drugs Chemically connects the antibody to the drug and controls its release Stable linkers and adcs can maintain antibody concentration in blood circulation, and they do not release the cytotoxic drug before it reaches its target, thus resulting in minimum off.
Linker tethering payload to antibody is vital for adc
This review provides an overview of linkers of 17 approved adcs and recent innovations in linker design, focusing on drug release triggers, bioconjugation strategies, the impact of spacers on hydrophilicity, traceless drug release, and linker architecture, as well as a discussion of the bystander effect, offering insights for the rational. Provides target specificity by recognizing an antigen expressed primarily on tumor cells
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