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Introduction traditional drug discovery involves a serial stage for the development of the new drug By automating and miniaturizing assays, hts significantly accelerates the identification of potential drug candidates or optimal process conditions and can be applied throughout the entire development path of a potential drug, from discovery to process development However, it remains a high failure rate in drug discovery.
Drug candidate effect on tau aggregation and cell viability They confirmed clinically relevant antagonistic and synergistic interactions among four distinct antitumor drugs by assessing the viability of a549 cells High throughput cell culture systems require uniformity, assay miniaturization, specific target identification, and process simplification
In this review, we detail the various techniques that researchers have used to face these challenges and explore cellular responses in a high throughput manner.
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