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Trastuzumab binding to her2 prevents homodimerization or heterodimerization (her2/her3) of the receptor, ultimately inhibiting the activation of mapk and pi3k/akt cellular signalling pathways. Rrently being evaluated as adjuvant treatment for early breast cancer Dm1 binds to tubulin in microtubules and inhibits microtubule function producing cell arrest and apoptosis
Trastuzumab emtansine binds to human epidermal growth factor 2 (her2) receptors and undergoes internalization and lysosomal degradation, resulting in increased targeted delivery of dm1 to malignant cells that overexpress her2.
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