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The protein database in normal smart has significant redundancy, even though identical proteins are removed "SMART"（Simple Modular Architecture Research Tool）是一个用于识别和分析蛋白质序列中的结构域和功能位点在线工具。 使用SMART进行蛋白序列分析的基本步骤如下： If you use smart to explore domain architectures, or want to find exact domain counts in various genomes, consider switching to genomic mode.
今天为大家介绍一个预测蛋白结构域的数据库：SMART (Simple Modular Architecture Research Tool)，它是一个用于蛋白质结构域鉴定、注释的在线分析工具。 SMART（Simple Modular Architecture Research Tool）是一款用于识别、注释和分析蛋白质结构域的工具，包含500多个结构域家族，主要集中于信号传导、细胞外和染色质相关蛋白。 在文本框中输入蛋白序列（可以只有氨基酸序列，也可以以fasta格式粘贴），把下面的要鉴定的复选框都选上，点击“Sequence SMART”就可以进行蛋白结构域分析了，速度非常快。
SMART（http://smart.embl.de/）是我们常用来 进行domain搜索和蛋白质注释的数据库， 它集成了很多蛋白结构预测和功能分析的工具，比如可以预测蛋白的一些二级结构：跨膜区（Transmembrane segments）、复合螺旋区（coiled coil regions）、信号肽（Signal peptides）、蛋白结构域.
SMART数据库，最新版v8，收录超1300蛋白结构域信息，覆盖uniprot、ensembl等数据库。 提供正常及基因组模式，支持蛋白ID和结构域检索，展示结构域图、蛋白相互作用、通路信息、同源群注释及转录后修饰。 本文记录一下通过TBTools一键分析基因结构域并利用工具可视化的具体步骤。 本文所用到的数据库是SMART，在TBTools的对应工具为 Batch SMART 。 文章介绍了如何使用在线工具SMART对蛋白序列进行结构域分析的基本步骤,从输入序列、选择数据库与设置,到分析结果和进一步的研究. Smart (a s imple m odular a rchitecture r esearch t ool) allows the identification and annotation of genetically mobile domains and the analysis of domain architectures
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